Dr. Kelson finds himself in a shocking new relationship with consequences that could change the world as he knows it, while Spike's encounter with Jimmy Crystal becomes a nightmare he can't escape.

Best friends Griff and Doug have always dreamed of remaking their all-time favorite movie "Anaconda." When a midlife crisis pushes them to finally go for it, they assemble a crew and head deep into the jungles of the Amazon to start filming. However, life soon imitates art when a gigantic anaconda with a thirst for blood starts hunting them down.